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Adrenocorticotropic hormone (ACTH) deficiency is a rare endocrine disorder caused by a lack of ACTH, a hormone produced by the pituitary gland. ACTH is responsible for stimulating the adrenal glands to produce cortisol, a hormone that helps regulate blood pressure, metabolism, and the body's response to stress. Without enough cortisol, the body cannot respond to stress and may experience a variety of symptoms, including fatigue, weight loss, low blood pressure, and low blood sugar. In some cases, ACTH deficiency can lead to Addison's disease, a condition in which the adrenal glands do not produce enough cortisol. Treatment for ACTH deficiency typically involves hormone replacement therapy to restore cortisol levels.
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