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Autosomal dominant cerebellar ataxia III (ADCA III) is a rare, inherited neurological disorder that affects the cerebellum, a part of the brain that controls movement and coordination. It is characterized by progressive difficulty with balance, coordination, and speech. Symptoms usually begin in childhood or adolescence and worsen over time. Common symptoms include difficulty walking, clumsiness, slurred speech, and difficulty with fine motor skills. Other symptoms may include difficulty swallowing, vision problems, and hearing loss. ADCA III is caused by a mutation in the ATXN3 gene, which is responsible for producing a protein called ataxin-3. This protein is important for the normal functioning of the cerebellum. There is currently no cure for ADCA III, but treatments can help manage symptoms and slow the progression of the disease.
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