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Description

Acute myeloid leukemia (AML) is a type of cancer that affects the blood and bone marrow. It is characterized by the rapid growth of abnormal white blood cells, called myeloblasts, which crowd out healthy blood cells. The t(8;21)(q22;q22) chromosomal translocation is a specific genetic abnormality that is found in some cases of AML. This translocation involves the exchange of genetic material between chromosomes 8 and 21, resulting in the fusion of two genes, RUNX1 and CBFB, which are involved in the regulation of cell growth and differentiation. This fusion gene leads to the production of an abnormal protein that causes the uncontrolled growth of myeloblasts.

Synonyms

• acute myeloid leukemia with t(8;21)(q22;q22)

Basic Lab Tests (measurements)

• vital signs
  •      temperature
• whole blood
  •      Pelger Huet cells
  •      myeloblasts
  •      mean corpuscular volume
  •      metamyelocytes
  •      hemoglobin F
  •      macrocytes
  •      promyelocytes
  •      Auer rods
  •      unidentified blasts
  •      myelocytes

Detailed Disease and Condition Information (use the search buttons below to find details on these topics)
All of the following must be considered when interpreting clinical findings and are too extensive to be covered on this site: