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Cold agglutinin disease is an autoimmune disorder in which the body produces antibodies called cold agglutinins that attack red blood cells when exposed to cold temperatures. This can cause anemia, fatigue, and other symptoms. It is usually caused by an underlying infection, such as mononucleosis, or by certain types of cancer. Treatment typically involves avoiding cold temperatures and taking medications to reduce the production of cold agglutinins.
All of the following must be considered when interpreting clinical findings and are too extensive to be covered on this site: