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Description

Cold agglutinin disease is an autoimmune disorder in which the body produces antibodies called cold agglutinins that attack red blood cells when exposed to cold temperatures. This can cause anemia, fatigue, and other symptoms. It is usually caused by an underlying infection, such as mononucleosis, or by certain types of cancer. Treatment typically involves avoiding cold temperatures and taking medications to reduce the production of cold agglutinins.

Symptoms (patient's findings)

• abdominal distention
• abdominal pain
• abnormal weight loss
• asthenia
• back pain
• crushing chest pain
• difficulty swallowing
• dizziness
• erectile dysfunction
• fatigue
• foreign body throat feeling
• headache
• pallor
• regurgitation
• shortness of breath
• swollen lymph nodes

Signs (examiner's findings)

• esophageal dyskinesia
• pallor
• splenomegaly

Basic Lab Tests (measurements)

• serum
  •      direct bilirubin
  •      lactate dehydrogenase
  •      iron binding capacity
  •      iron
  •      bilirubin
  •      indirect bilirubin
• urine
  •      brown urine
  •      urine color
  •      red-brown urine
  •      hemoglobin
  •      urobilinogen
  •      red urine
  •      orange urine
• vital signs
  •      temperature
  •      systolic blood pressure
  •      blood pressure
• whole blood
  •      fluorescent aerolysin cells
  •      mean corpuscular volume
  •      hemoglobin
  •      polychromasia
  •      mean corpuscular hemoglobin concentration
  •      macrocytes
  •      spherocytes
  •      hematocrit
  •      glycosylated hemoglobin
  •      erythrocyte phagocytosis
  •      erythrocytes
  •      reticulocytes

Detailed Disease and Condition Information (use the search buttons below to find details on these topics)
All of the following must be considered when interpreting clinical findings and are too extensive to be covered on this site: