Simplifying Science Descipher Logo   
Disease or Condition — Blood Disorders:
cold agglutinin disease

Information displayed below is a subset of the entire knowledge base and may be incorrect, or incomplete intensionally or inadvertently. If you detect a serious error or want access to the complete knowledge base, please contact us.


Cold agglutinin disease is an autoimmune disorder in which the body produces antibodies called cold agglutinins that attack red blood cells when exposed to cold temperatures. This can cause anemia, fatigue, and other symptoms. It is usually caused by an underlying infection, such as mononucleosis, or by certain types of cancer. Treatment typically involves avoiding cold temperatures and taking medications to reduce the production of cold agglutinins.

Symptoms (patient's findings)
  • abdominal distention
  • abdominal pain
  • abnormal weight loss
  • asthenia
  • back pain
  • crushing chest pain
  • difficulty swallowing
  • dizziness
  • erectile dysfunction
  • fatigue
  • foreign body throat feeling
  • headache
  • pallor
  • regurgitation
  • shortness of breath
  • swollen lymph nodes
Signs (examiner's findings)
  • esophageal dyskinesia
  • pallor
  • splenomegaly
Basic Lab Tests (measurements)

Detailed Disease and Condition Information (use the search buttons below to find details on these topics)
All of the following must be considered when interpreting clinical findings and are too extensive to be covered on this site: