Simplifying Science Descipher Logo   
Drug or Toxic Substance:
4-aminofolic acid
Do need help with a possible poisoning or toxicity?
Have you experienced a drug reaction?

Information displayed below is a subset of the entire knowledge base and may be incomplete intensionally or inadvertently. If you detect a serious error or want access to the complete knowledge base, please contact us.


Aminopterin is a folic acid antagonist, meaning it blocks the action of folic acid in the body. It is used in chemotherapy to treat certain types of cancer. It is also used to treat rheumatoid arthritis and psoriasis.

Aminopterin is toxic and can cause serious side effects, including bone marrow suppression, anemia, nausea, vomiting, diarrhea, and hair loss. It can also cause birth defects if taken during pregnancy.

Associated brand names:
  ▸ Metotrexate
  ▸ Rheumatrex
  ▸ Trexall
  ▸ Emthexate
  ▸ Folex

  • 4-aminopteroylglutamic acid
  • aminopterin
  • aminopteroylglutamic acid
  • antineoplastic
  • antipsoriatic
  • dihydrofolate reductase inhibitor
  • immunosuppressant
  • teratogen

Detailed Disease Information (use the search buttons below to find details on these topics from other web sources)
All of the following must be considered when interpreting clinical findings and are too extensive to be covered on this site: