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Description

The clinical test for heat-stable alkaline phosphatase (HAP) is used to measure the activity of the enzyme in a patient's serum. The test is used to diagnose certain diseases, such as liver disease, bone disorders, and certain types of cancer.

To obtain the HAP from a patient's serum, a sample of the patient's blood is collected and centrifuged to separate the serum from the other components of the blood. The serum is then heated to denature the proteins, and the HAP is then isolated from the denatured proteins. The HAP is then measured using a spectrophotometer to determine the activity of the enzyme.

Synonyms

• heat-stable ALP

Other Sample Sources for This Test

• plasma

Some Diseases Associated with an Abnormal Heat-stable Alkaline Phosphatase

• diabetes mellitus
• normal pregnancy
• secondary malignant bone or bone marrow neoplasm
• malignant female breast neoplasm
• infectious mononucleosis
• anemia
• chronic liver disease
• congestive heart failure
• hematologic malignancy
• Type 1 diabetes mellitus
• biliary disorder
• malignant colorectal neoplasm

Detailed Laboratory Testing Information (use the custom search buttons below to find details on these topics)

All of the following must be considered when interpreting clinical findings and are too extensive to be covered on this site: