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Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune disorder in which red blood cells are destroyed by the body's own immune system. It is characterized by episodes of hemoglobinuria, or the presence of hemoglobin in the urine, which occur after exposure to cold temperatures. Symptoms of PCH include fatigue, pallor, and dark urine. Treatment typically involves the use of immunosuppressive medications to reduce the body's immune response and prevent further destruction of red blood cells.
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