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Nephrogenic diabetes insipidus (NDI) is a rare disorder that affects the kidneys' ability to concentrate urine and regulate the body's water balance. It is caused by a defect in the kidneys' ability to respond to the hormone vasopressin, which is responsible for controlling the amount of water that is reabsorbed from the kidneys back into the bloodstream. As a result, people with NDI produce large amounts of urine that is very dilute, leading to frequent urination and dehydration. Treatment for NDI typically involves medications that help the kidneys respond to vasopressin, as well as lifestyle changes to help manage the symptoms.
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