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Renal tubular acidosis (RTA) is a disorder that occurs when the kidneys are unable to excrete acid properly. Type I RTA is caused by a defect in the ability of the kidneys to secrete hydrogen ions into the urine. This results in an accumulation of acid in the body, leading to a decrease in the pH of the blood. Symptoms of type I RTA include fatigue, muscle weakness, nausea, vomiting, and dehydration. Treatment typically involves the use of medications to reduce the amount of acid in the body and to correct electrolyte imbalances.
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